What if you could have at your fingertips all the published 2D-gel electrophoresys data relevant to your research?
These example applications are within the scope of BioDiscovery, a software under development at BioDigitalvalley, which will render you able to make use of relevant 2Dgel data for guiding your proteomic research toward more productive and cost-effective approaches.
The two-dimensional electrophoresis (2-DE) pattern of proteins is thought to be specifically related to the physiological or pathological condition at the moment of sample preparation. On this ground, most proteomic studies move to identify specific hallmarks for a number of different conditions. However, the information arising from these investigations is often incomplete due to inherent limitations of the technique, to extensive protein post-translational modifications and sometimes to the paucity of available samples.
On the other side, the meta-analysis of proteomic data can provide valuable information pertinent to various biological processes that otherwise remains hidden.
In a two year research effort, we intend to apply this approach to ascertain the validity of known Parkinson's Disease biomarkers, while keeping an eye on possible new biomarkers obtained studying an homogeneous population of 50 patients. Our core technology ProteinQuest™ will be used for relevant 2D gel, while blood samples will be collected from patients and controls; aim of the project will be the crossing of experimental with the meta-analysis of the scientific literature.
The project will be run in collaboration with the Aosta Regional Hospital and the University of Insubria.